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      Inflammatory Conditions


There are several inflammatory conditions including:

 
 

   

Acne

       

The quest for medications and cosmetic measures to combat acne continues to be a major research and development initiative in the pharmaceutical and personal care industries. Acne is reported to affect about 17 million individuals in the United States alone. Its disfiguring effects have far-reaching socio-psychological consequences, particularly in view of the fact that a vast majority of the sufferers are adolescents and young adults.

Acne, most commonly encountered as Acne vulgaris , is a follicular disorder of the skin occurring predominantly in specialized pilosebaceous units on the face and neck. Acne is characterized by presence of open comedones (black heads) and closed comedones (microcysts).

Causes for acne are:

  • Seborrhea (increased sebum release)
  • Imbalance in the androgen metabolism
  • Increase in the levels of 5 a - reductase activity in sebaceous glands
  • Proliferation of Propionibacterium acnes (P.acnes) which is responsible for inflammatory reactions.
  • Problems in keratinization (hyperkeratosis) leading to accumulation of sebum on which acnes thrive to release free fatty acids which
    are irritants.

Ultraviolet (UV) rays from sun are a double-edged sword. Although UV B light at carefully controlled levels may have mild anti-inflammatory and/or antimicrobial effects, and tanning tends to hide acne lesions, exposure may also manifest comedogenic effects in some individuals. UV light is reported to thicken the skin and to promote hyperkeratosis of both the skin surface and the follicle, providing an explanation for the observation in clinical dermatological practice that acne patients tend to get worse shortly after returning from summer vacation. Additionally, the action of UV rays on keratinocytes triggers the release of specific inflammatory mediators, which act on melanocytes augmenting the activity of the enzyme tyrosinase. Tyrosinase is a rate-limiting enzyme involved in the synthesis of melanin; excessive tyrosinase activity therefore leads to darkening of the skin.

Conventional treatment agents such as retinoids and benzoyl peroxide frequently have irritating side effects, photosensitization and occasional contact sensitization. Oral Isotretinoin treatments are known to be associated with side effects including chapped lips, and dry eye syndrome resulting in xerosis.

In recent years, natural approaches to combating acne and its disfiguring effects have gained popularity. Several botanicals with a history of use in traditional cultures have entered the growing cosmeceuticals market. With fewer adverse side effects and the added advantage of multifunctionality, botanicals are increasingly being used in mainstream cosmetic products, including acne-fighting compositions.

Sabinsa Products for Anti-Acne

  • Policosanol, Umbelliferin - Seborrhea (increased sebum release) control
  • Boswellin CG, Oleuropein - Controls 5-alpha reductase activity in sebaceous glands.
  • Coleus Oil, Galanga Extract, Neem Oil Limonoids - Controls p roliferation of Propionibacterium acnes (P.acnes). (inflammatory factor)
  • Boswellin CG, Glabridin Green tea extract - A nti-inflammatory.
 
 

  

Allergic Contact Dermatitis

     
  • This is an inflammatory skin response to allergens.
  • It is also known as "delayed contact hypersensitivity" as these type of skin response takes relatively long period (24hrs).
  • These are cell mediated immune responses. Lymphocytes of the cells are "programmed" to recognize the specific chemical nature of the allergen, which triggers immune response.
  • ACD is characterized by hyperproliferative epidermis, intracellular edema, redness, itching and irritation.
  •  
     

      

    Skin irritation

         

    Skin Irritation has been described by exclusion as localized inflammation not mediated by either sensitized lymphocytes or by antibodies (a process not involving the immune system) Skin Irritation depends on intrinsic factors like, genetic disposition of the consumer and extrinsic factors like climatic or consumer occupation.

    Skin Irritants, mediators of irritant reaction disrupt cell functions and/or trigger the release , formation or activation of autocoids that produce local increase in blood flow, increase vascular permeability or damage cells and cause local skin inflammation.

    Types of skin irritants:

    Primary Irritants : produce irritation as a result of single exposure.

    Cumulative Irritants: produce inflammation following repeated application to the same area of skin.

     
     

    Pruritis

     
     

    Pruritus is a severe itching reaction that is often associated with urticaria, the eruption of a skin rash which may consist of red spots, scaly patches or blisters.

     
     
     
     

    Various causes of Pruritus,

         
     

    •  Localized Pruritus- affect a particular site of the body e.g. Seborrheic eczema (scalp),    Scabies(fingers) etc.
    •  General Pruritus

     
    External causes like climatic, foreign body, chemical, parasitic contacts,etc. Skin Diseases causing itchiness like contact dermatitis, urtcaria, scabies, psoriasis, dry skin etc.
     
     
     

    Urticaria (Immediate Contact Reaction)

     
     

    Urticaria are characterized by stinging, tingling or a burning sensation within few minutes to an hour of contact with the irritant. Erythema, whealing and hives are characteristic features of Urticaria.

     
     
     
     

    Two main mechanisms of Contact urticaria:

    •  Immunological-The molecules of a contact urticant react with specific Immunoglobulin E (IgE) molecules attached to the mast membranes.

    •  Non-immunological- It is the most common form and occurs without previous exposure in most individual. The reaction remains localized and does not cause systemic symptoms.

     
     
     

    Sabinsa Products for Skin Irritation

     
     
    • Umbelliferin ®
    • Rosemary extract
    • Rosmarinic acid
    • Boswellin ®
    • Venocin
     
     
     

     

    General Anti-Inflammatory products from Sabinsa

     
     

     

     
     
    • Umbelliferin® - Disruption or Loss of Integrity of Stratum Corneum (Increased skin permeability)
    • Tetrahydrocurcuminoids - Formation of Lipid peroxides due to the interaction between free radicals and unsaturated lipids of the cell membranes
    • Boswellin CG, Umbelliferin® - Release of Pro-Inflammatory mediators (metabolic pathways, cyclooxygenase and lipooxygenase)
    • Boswellin CG - Cytokines release can activate epidermal proliferation and trigger inflammatory reactions

     

     
     

     

     
     
     


     

    Disclaimer: The information on this website is for general purposes only. Users are urged to check the validity of patents if any, on any of these items for their intended use.


     
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