Hydroquinone, which is extensively used in the treatment of hyperpigmentary disorders is associated with known side effects. Safer, natural depigmenting actives are therefore being explored. A randomized,  placebo controlled study in 50 human subjects, showed that the depigmenting effects of 0.25 percent tetrahydrocurcumin cream and 4 percent hydroquinone cream were comparable in a four week trial.

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